Incident diuretic drug use and adverse respiratory events among older adults with chronic obstructive pulmonary disease.

ABSTRACT:

Aims

Diuretic drugs may theoretically improve respiratory health outcomes in chronic obstructive pulmonary disease (COPD) through several possible mechanisms, but they might also lead to respiratory harm. We evaluated the association of incident oral diuretic drug use with respiratory-related morbidity and mortality among older adults with COPD.

Methods

This was a population-based, retrospective cohort study using health administrative data from Ontario, Canada, for the period 2008-2013. We identified adults aged 66 years and older with nonpalliative COPD using a validated algorithm. Respiratory-related morbidity and mortality were evaluated within 30 days of incident oral diuretic drug use compared to nonuse using Cox proportional hazard regression and applying inverse prob

SUBMITTER: Vozoris NT 

PROVIDER: S-EPMC5809361 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature