Ontology highlight
ABSTRACT:
SUBMITTER: Karakashev S
PROVIDER: S-EPMC5809368 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180212 1
CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers. However, clinically applicable cancer therapeutic strategies based on CARM1 expression remain to be explored. Here, we report that EZH2 inhibition is effective in CARM1-expressing epithelial ovarian cancer. Inhibition of EZH2 activity using a clinically applicable small molecule inhibitor significantly suppresses the growth of CARM1-expre ...[more]