Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.

ABSTRACT:

Background

Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than other stroke subtypes in acute ischemic stroke (AIS) patients.

Methods

This study was a retrospective review of prospectively collected clinical and imaging database of AIS patients who underwent CT perfusion. Hypoperfusion was defined as Tmax >6 s. The average relative permeability-surface area product (rPS), reflecting the BBBP, was calculated within the hypoperfusion region (rPS_hypo). CE was diagnosed according to the international Trial of Org 101

SUBMITTER: Liu C 

PROVIDER: S-EPMC5809413 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature