Infectious Sporozoites of Plasmodium berghei Effectively Activate Liver CD8α⁺ Dendritic Cells.

ABSTRACT: Immunization with radiation-attenuated sporozoites (RAS) shown to confer complete sterile protection against Plasmodia liver-stage (LS) infection that lasts about 6 to 9 months in mice. We have found that the intermittent infectious sporozoite challenge to immune mice following RAS vaccination extends the longevity of sterile protection by maintaining CD8⁺ T cell memory responses to LS infection. It is reported that CD8α⁺ dendritic cells (DCs) are involved in the induction of LS-specific CD8⁺ T cells following RAS or genetically attenuated parasite (GAP) vaccination. In this study, we demonstrate that CD8α⁺ DCs respond differently to infectious sporozoite or RAS inoculation. The higher accumulation and activation of CD8α⁺ DCs wa

SUBMITTER: Parmar R 

PROVIDER: S-EPMC5809440 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature