In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo.

ABSTRACT: Memory CD8⁺ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8⁺ T cell effector subsets to persist and become memory cells has not been fully characterized. Type 1 CD8⁺ T (Tc1) cells produce interferon-γ and are endowed with high cytotoxic capacity, whereas IL-17-producing CD8⁺ T (Tc17) cells are less cytotoxic but display enhanced self-renewal capacity. We sought to evaluate the functional properties of in vitro-generated Tc17 cells and elucidate their potential to become long lasting memory cells. Our results show that in vitro-generated Tc17 cells display a greater in vivo persisten

SUBMITTER: Flores-Santibanez F 

PROVIDER: S-EPMC5809442 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature