Regional Differences in Striatal Neuronal Ensemble Excitability Following Cocaine and Extinction Memory Retrieval in Fos-GFP Mice.

ABSTRACT: Learned associations between drugs of abuse and the drug administration environment have an important role in addiction. In rodents, exposure to a drug-associated environment elicits conditioned psychomotor activation, which may be weakened following extinction (EXT) learning. Although widespread drug-induced changes in neuronal excitability have been observed, little is known about specific changes within neuronal ensembles activated during the recall of drug-environment associations. Using a cocaine-conditioned locomotion (CL) procedure, the present study assessed the excitability of neuronal ensembles in the nucleus accumbens core and shell (NAc^core and NAc^shell), and dorsal striatum (DS) following cocaine conditioning and EXT in Fos-GFP mice that express green flu

SUBMITTER: Ziminski JJ 

PROVIDER: S-EPMC5809776 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature