The Impact of Combinations of Alcohol, Nicotine, and Cannabis on Dynamic Brain Connectivity.

ABSTRACT: Alcohol, nicotine, and cannabis are among the most commonly used drugs. A prolonged and combined use of these substances can alter normal brain wiring in different ways depending on the consumed cocktail mixture. Brain connectivity alterations and their change with time can be assessed using functional magnetic resonance imaging (fMRI) because of its spatial and temporal content. Here, we estimated dynamic functional network connectivity (dFNC) as derived from fMRI data to investigate the effects of single or combined use of alcohol, nicotine, and cannabis. Data from 534 samples were grouped according to their substance use combination as controls (CTR), smokers (SMK), drinkers (DRN), smoking-and-drinking subjects (SAD), marijuana users (MAR), smoking-and-marijuana users (SAM), marijuana-a

SUBMITTER: Vergara VM 

PROVIDER: S-EPMC5809800 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature