Citral induced apoptosis in MDA-MB-231 spheroid cells.

ABSTRACT:

Background

Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. However, the potential of citral to specifically target the drug resistant breast cancer cells has not yet been tested, which was the focus of our current study.

Methods

The cytotoxic activity of citral was first tested on MDA-MB-231 cells in vitro by MTT assay. Subsequently, spheroids of MDA-MB-231 breast cancer cells were developed and treated with citral at different concentrations. Doxorubicin, cisplatin and tamoxifen were

SUBMITTER: Nigjeh SE 

PROVIDER: S-EPMC5809808 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature