Genetic determinants of sporadic breast cancer in Sri Lankan women.

ABSTRACT:

Background

While a range of common genetic variants have been identified to be associated with risk of sporadic breast cancer in several Western studies, little is known about their role in South Asian populations. Our objective was to examine the association between common genetic variants in breast cancer related genes and risk of breast cancer in a cohort of Sri Lankan women.

Methods

A case-control study of 350 postmenopausal women with breast cancer and 350 healthy postmenopausal women was conducted. Genotyping using the iPLEX GOLD assay was done for 56 haplotype-tagging single nucleotide polymorphisms (SNPs) in 36 breast cancer related genes. Testing for association was done using an additive genetic model. Odds ratios and 95% confidence intervals were calculated using

SUBMITTER: Sirisena ND 

PROVIDER: S-EPMC5809862 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature