Antigenic cartography of H1N1 influenza viruses using sequence-based antigenic distance calculation.

ABSTRACT:

Background

The ease at which influenza virus sequence data can be used to estimate antigenic relationships between strains and the existence of databases containing sequence data for hundreds of thousands influenza strains make sequence-based antigenic distance estimates an attractive approach to researchers. Antigenic mismatch between circulating strains and vaccine strains results in significantly decreased vaccine effectiveness. Furthermore, antigenic relatedness between the vaccine strain and the strains an individual was originally primed with can affect the cross-reactivity of the antibody response. Thus, understanding the antigenic relationships between influenza viruses that have circulated is important to both vaccinologists and immunologists.

Results

Here we develo

SUBMITTER: Anderson CS 

PROVIDER: S-EPMC5809904 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature