Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes.

ABSTRACT: BACKGROUND:Astrocytes have attracted increasing attention over recent decades for their role in neuroinflammation. Histamine, a major aminergic brain neurotransmitter, has an important influence on the main activities of astrocytes, such as ion homeostasis, energy metabolism, and neurotransmitter clearance. However, little is known about the impact of histamine on astrocyte immunomodulatory function. METHODS:The expression of all known histamine receptor subtypes was examined in primary astrocytes. Then, primary astrocytes were pretreated with selective histamine receptor antagonists and stimulated with histamine. Cellular activation, proinflammatory cytokine production, and expression of neurotrophic factors were assessed. RESULTS:Astrocytes could constitutively express three histamine re

SUBMITTER: Xu J 

PROVIDER: S-EPMC5809996 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature