MethCNA: a database for integrating genomic and epigenomic data in human cancer.

ABSTRACT:

Background

The integration of DNA methylation and copy number alteration data promises to provide valuable insight into the underlying molecular mechanisms responsible for cancer initiation and progression. However, the generation and processing of these datasets are costly and time-consuming if carried out separately. The Illumina Infinium HumanMethylation450 BeadChip, initially designed for the evaluation of DNA methylation levels, allows copy number variant calling using bioinformatics tools.

Results

A substantial amount of Infinium HumanMethylation450 data across various cancer types has been accumulated in recent years and is a valuable resource for large-scale data analysis. Here we present MethCNA, a comprehensive database for genomic and epigenomic data integration i

SUBMITTER: Deng G 

PROVIDER: S-EPMC5810021 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature