NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma.

ABSTRACT:

Background

Nijmegen breakage syndrome 1 (NBS1), as a key protein in the DNA double-strand breaks (DSBs) repair pathway, plays an important role in maintaining genomic stability. Although single nucleotide polymorphisms (SNPs) in NBS1 have frequently been studied in multiple cancers, the relationships of two functional NBS1 polymorphisms (rs2735383 and rs1805794) with laryngeal carcinoma are yet unclear. Therefore, in the present study, we performed a case-control study including 342 cases and 345 controls to analyze the associations between two polymorphisms of NBS1 and the risk of laryngeal carcinoma.

Methods

We used the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to determine the genotypes of the functional SNPs in NBS1 gene.

Res

SUBMITTER: Hu X 

PROVIDER: S-EPMC5810033 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature