Impairment of social behaviors in Arhgef10 knockout mice.

ABSTRACT:

Background

Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region is ARHGEF10. A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear.

Methods

We generated Arhgef10 knockout mice as a model of ASD and characterized the social behavior and the biochemical changes in the brains of the knockout mice.

Results

Compared with their wild-type littermates, the Arhgef10-depleted mice

SUBMITTER: Lu DH 

PROVIDER: S-EPMC5810065 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature