Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts.

ABSTRACT:

Introduction

Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline.

Methods

For 912 nonapolipoprotein ε4 middle-aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 '523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed.

Results

For FH negative participants, gene-dose preservation of memory and global cognition was seen for "very long" versus "short" carriers. For FH positive, an opposite gene-dose decline was seen for very long versus short carriers. M

SUBMITTER: Willette AA 

PROVIDER: S-EPMC5810361 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature