Dectin-1 plays an important role in host defense against systemic Candida glabrata infection.

ABSTRACT: Candida glabrata is the second most common pathogen of severe candidiasis in immunocompromised hosts, following C. albicans. Although C. glabrata and C. albicans belong to the same genus, they are phylogenetically distinct. C-type lectin receptors (CLRs), acting as pattern-recognition receptors (PRRs), play critical roles in host defense against C. albicans infections. However, our understanding of the specific roles of CLRs in host defense against C. glabrata is limited. Here, we explored the potential roles of the C-type lectins Dectin-1 and Dectin-2 in host defense against C. glabrata. We found that both Dectin-1-deficient mice (Dectin-1^-/-) and Dectin-2-deficient mice (Dectin-2^-/-) are more susceptible to C. glabrata infection. Dectin-1confers host higher sensitiv

SUBMITTER: Chen SM 

PROVIDER: S-EPMC5810470 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature