Effects of silica-gentamicin nanohybrids on osteogenic differentiation of human osteoblast-like SaOS-2 cells.

ABSTRACT:

Introduction

In recent years, there has been an increasing interest in silica (SiO₂) nanoparticles (NPs) as drug delivery systems. This interest is mainly attributed to the ease of their surface functionalization for drug loading. In orthopedic applications, gentamicin-loaded SiO₂ NPs (nanohybrids) are frequently utilized for their prolonged antibacterial effects. Therefore, the possible adverse effects of SiO₂-gentamicin nanohybrids on osteogenesis of bone-related cells should be thoroughly investigated to ensure safe applications.

Materials and methods

The effects of SiO₂-gentamicin nanohybrids on the cell viability and osteogenic differentiation of human osteoblast-like SaOS-2 cells were investigated, together with native SiO

SUBMITTER: He W 

PROVIDER: S-EPMC5810519 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature