Ontology highlight
ABSTRACT:
SUBMITTER: Darmanis S
PROVIDER: S-EPMC5810554 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell reports 20171001 5
Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells in a cohort of four patients. We obtained cells from the tumor core as well as surrounding peripheral tissue. Our analysis revealed cellular variation in the tumor's genome and transcriptome. We were also able to identify infiltrating neoplastic cells in regions peripheral to the core lesions. De ...[more]