Shining dead bone-cause for cautious interpretation of [¹⁸F]NaF PET scans.

ABSTRACT: Background and purpose - [¹⁸F]Fluoride ([¹⁸F]NaF) PET scan is frequently used for estimation of bone healing rate and extent in cases of bone allografting and fracture healing. Some authors claim that [¹⁸F]NaF uptake is a measure of osteoblastic activity, calcium metabolism, or bone turnover. Based on the known affinity of fluoride to hydroxyapatite, we challenged this view. Methods - 10 male rats received crushed, frozen allogeneic cortical bone fragments in a pouch in the abdominal wall on the right side, and hydroxyapatite granules on left side. [¹⁸F]NaF was injected intravenously after 7 days. 60 minutes later, the rats were killed and [¹⁸F]NaF uptake was visualized in a PET/CT scanner. Specimens were retrieved for micro CT and his

SUBMITTER: Bernhardsson M 

PROVIDER: S-EPMC5810820 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature