Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.

ABSTRACT:

Background

The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspects of developmental biology.

Discussion

Aberrant Wnt signaling underlies a wide range of pathologies in humans including tumor initiation, tumor growth, cell senescence, cell death, differentiation and metastasis. The inhibition of Wnt signaling offers a novel approach for anticancer therapeutics.

Conclusion

Focusing on recent developments, we reviewed the small-molecule inhibitors targeting various components of Wnt signaling pathways and the progress from the discovery of lead compounds to highly potent inhibitors with sig

SUBMITTER: Zheng S 

PROVIDER: S-EPMC5810846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature