Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways.

ABSTRACT: It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their aerodynamic properties; these particles tend to align with the flow and thus stay longer airborne relative to their spherical counterpart, due to higher drag forces that resist sedimentation. Together with a high surface-to-volume ratio, such characteristics may render non-spherical particles, and fibers in particular, potentially attractive airborne carriers for drug delivery. Until present, however, our understanding of the dynamics of inhaled aerosols in the distal regions of the lungs has been mostly limited to spherical particles. In an effort to unravel the fate of non

SUBMITTER: Shachar-Berman L 

PROVIDER: S-EPMC5810903 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature