Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening.

ABSTRACT: Microphysiological systems and organs-on-chips promise to accelerate biomedical and pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from addressing the physiological accuracy of the model tissues, there is a pressing need for improving the throughput of these platforms. To do so, scalable data acquisition strategies must be introduced. To this end, we here present an instrumented 24-well plate platform for higher-throughput studies of engineered human stem cell-derived cardiac muscle tissues that recapitulate the laminar structure of the native ventricle. In each well of the platform, an embedded flexible strain gauge provides continuous and non-invasive readout of the contractile stress and beat rate of an engineered cardiac tissue. The sensors are b

SUBMITTER: Lind JU 

PROVIDER: S-EPMC5810940 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature