Design, Synthesis and Preliminary Antimicrobial Evaluation of N-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins.

ABSTRACT: A series of N-alkyl tethered C-5 functionalized bis-isatins were synthesized and evaluated for antimicrobial activity against pathogenic microorganisms. The preliminary evaluation studies revealed the compound 4t, with an optimal combination of bromo-substituent at the C-5 position of isatin ring along with propyl chain linker being most active among the synthesized series exhibiting an IC₅₀ value of 3.72 μM against Trichomonas vaginalis while 4j exhibited an IC₅₀ value of 14.8 μM against Naegleria fowleri, more effective than the standard drug Miltefosine. The compound 3f with an octyl spacer length was the most potent among the series against Giardia lamblia with an IC₅₀ of 18.4 μM while 3d exhibited

SUBMITTER: Singh A 

PROVIDER: S-EPMC5810968 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature