Immature platelet fraction and thrombopoietin in patients with liver cirrhosis: A cohort study.

ABSTRACT:

Background and aims

Thrombocytopenia occurs frequently in patients with cirrhosis. The immature platelet fraction (IPF%) is measured to differentiate the causes of thrombocytopenia. To date the relevance of thrombopoietin (TPO) in the context of cirrhosis is unknown. The aim of our study was to investigate the cause of thrombocytopenia in patients with liver cirrhosis by measuring IPF%, TPO and spleen size. In addition we examined the use of IPF% to evaluate the severity of cirrhosis and its complications.

Methods

Overall, we included 88 in-patients with cirrhosis in our study. The collected data comprises current health status, blood parameters, severity of cirrhosis evaluated by Child-Pugh score and MELD score, spleen diameter, ascites and esophageal varices. The IPF% was

SUBMITTER: Rauber P 

PROVIDER: S-EPMC5810997 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature