Capacity of non-invasive hepatic fibrosis algorithms to replace transient elastography to exclude cirrhosis in people with hepatitis C virus infection: A multi-centre observational study.

ABSTRACT:

Introduction

Achievement of the 2030 World Health Organisation (WHO) global hepatitis C virus (HCV) elimination targets will be underpinned by scale-up of testing and use of direct-acting antiviral treatments. In Australia, despite publically-funded testing and treatment, less than 15% of patients were treated in the first year of treatment access, highlighting the need for greater efficiency of health service delivery. To this end, non-invasive fibrosis algorithms were examined to reduce reliance on transient elastography (TE) which is currently utilised for the assessment of cirrhosis in most Australian clinical settings.

Materials and methods

This retrospective and prospective study, with derivation and validation cohorts, examined consecutive patients in a tertiary refer

SUBMITTER: Kelly ML 

PROVIDER: S-EPMC5811020 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature