Spatial overlap links seemingly unconnected genotype-matched TB cases in rural Uganda.

ABSTRACT:

Introduction

Incomplete understanding of TB transmission dynamics in high HIV prevalence settings remains an obstacle for prevention. Understanding where transmission occurs could provide a platform for case finding and interrupting transmission.

Methods

From 2012-2015, we sought to recruit all adults starting TB treatment in a Ugandan community. Participants underwent household (HH) contact investigation, and provided names of social contacts, sites of work, healthcare and socializing, and two sputum samples. Mycobacterium tuberculosis culture-positive specimens underwent 24-loci MIRU-VNTR and spoligotyping. We sought to identify epidemiologic links between genotype-matched cases by analyzing social networks and mapping locations where cases reported spending ≥12 hours over

SUBMITTER: Chamie G 

PROVIDER: S-EPMC5811029 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature