Monitoring tumor response to the vascular disrupting agent CKD-516 in a rabbit VX2 intramuscular tumor model using PET/MRI: Simultaneous evaluation of vascular and metabolic parameters.

ABSTRACT:

Objectives

To determine whether the CKD-516 produces a significant change in vascular and metabolic parameters in PET/MRI.

Materials and methods

With institutional Animal Care and Use Committee approval, 18 VX2 carcinoma tumors implanted in bilateral back muscles of 9 rabbits were evaluated. Serial PET/MRI were performed before, 4 hours after and 1-week after vascular disrupting agent, CKD-516 at a dose of 0.7 mg/kg (treated group, n = 10) or saline (control group, n = 8) administration. PET/MRI-derived parameters and their interval changes were compared between the treated and control group by using the linear mixed model. Each parameter within each group was also compared by using the linear mixed model.

Results

Changes of the volume transfer coefficient (Ktrans) an

SUBMITTER: Ahn SY 

PROVIDER: S-EPMC5811032 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature