Direct catalytic cross-coupling of alkenyllithium compounds.

ABSTRACT: A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions. In addition (1-ethoxyvinyl)lithium can be efficiently converted into substituted vinyl ethers which, after hydrolysis, give readily access to the corresponding methyl ketones in a one pot procedure.

SUBMITTER: Hornillos V 

PROVIDER: S-EPMC5811103 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature