Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions.

ABSTRACT: Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or sulfone partners gives bridged hydroxy-diketopiperazine (DKP) products resulting from a novel Michael addition-ring closure.

SUBMITTER: Cabanillas A 

PROVIDER: S-EPMC5811140 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature