<i>Wilms Tumor 1b</i> defines a wound-specific sheath cell subpopulation associated with notochord repair.

ABSTRACT: Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expresses Wilms Tumor (WT) 1b following injury in zebrafish. We show that localized damage leads to Wt1b expression in sheath cells, and that wt1b⁺cells migrate into the wound to form a stopper-like structure, likely to maintain structural integrity. Wt1b⁺sheath cells are distinct in expressing cartilage and vacuolar genes, and in repressing a Wt1b-p53 transcriptional programme. At the wound, wt1b⁺and entpd5⁺ cells constitute separate, tightly-associated subpopulations. Surpris

SUBMITTER: Lopez-Baez JC 

PROVIDER: S-EPMC5811212 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature