Optimized inversion-time schedules for quantitative T₁ measurements based on high-resolution multi-inversion EPI.

ABSTRACT:

Purpose

Demonstrate an optimized multi-inversion echo-planar imaging technique to accelerate quantitative T₁ mapping by judicious selection of inversion times for each slice.

Methods

Slice ordering is optimized to maximize discrimination between tissues with different T₁ values. The optimized slice orderings are tested in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology phantom and compared with an unoptimized 21-measurement acquisition. The utility of the method is demonstrated in a healthy subject in vivo at 3 T and validated with a gold-standard inversion-recovery sequence. The in vivo precision of our technique was tested by repeated scans of the same subject within a scan session and across

SUBMITTER: Cohen O 

PROVIDER: S-EPMC5811323 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature