Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study.

ABSTRACT:

Purpose

To evaluate the echo dependence of 3D ultrashort echo time (TE) quantitative susceptibility mapping (3D UTE-QSM) and effective transverse relaxation rate ( R2*) measurement in the setting of high concentrations of iron oxide nanoparticles.

Methods

A phantom study with iron concentrations ranging from 2 to 22 mM was performed using a 3D UTE Cones sequence. Simultaneous QSM processing with morphology-enabled dipole inversion (MEDI) and R2* single exponential fitting was conducted offline with the acquired 3D UTE data. The dependence of UTE-QSM and R2* on echo spacing (ΔTE) and first TE (TE₁ ) was investigated.

Results

A linear relationship was observed between UTE-QSM measurement and iron concentration up to 22 mM only, with the minimal TE₁

SUBMITTER: Lu X 

PROVIDER: S-EPMC5811338 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature