Murine pulmonary imaging at 7T: T2* and T₁ with anisotropic UTE.

ABSTRACT:

Purpose

To measure the T2* and T₁ of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage.

Methods

Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and T₁ of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T.

Results

Lung parenchyma T2* of 17- to 23-week-old mice at 7T was 0.395 ± 0.033 ms. T₁ of lung and left- and right-heart ventricles was 1452.5 ± 87.0 ms, 1810.5 ± 54.6 ms, and 1602.6 

SUBMITTER: Guo J 

PROVIDER: S-EPMC5811363 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature