Exploring the genomic basis of early childhood caries: a pilot study.

ABSTRACT:

Objective

A genetic component in early childhood caries (ECC) is theorized, but no genome-wide investigations of ECC have been conducted. This pilot study is part of a long-term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC-associated genetic loci.

Methods

The study's community-based sample comprised 212 children (mean age=39 months; range = 30-52 months; males = 55%; Hispanic/Latino = 35%, African-American = 32%; American Academy of Pediatric Dentistry definition of ECC prevalence = 38%). Approximately 2.4 million single nucleotide polymorphisms (SNPs) were genotyped using DNA purified from saliva. A P < 5 × 10^-8 criterion was used for genome-wide significance. SNPs with P < 5 × 10

SUBMITTER: Ballantine JL 

PROVIDER: S-EPMC5811369 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature