A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI.

ABSTRACT:

Purpose

To develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species.

Theory and methods

A multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7 T. Cramér-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determ

SUBMITTER: Ludwig KD 

PROVIDER: S-EPMC5811371 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature