Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.

ABSTRACT:

Introduction

Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations.

Methods

The purpose of this study was to determine whether single-nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) differences contribute to lipid variation among African Americans ([AAs], N = 739) in the Genetic Epidemiology Network of Arteriopathy (GENOA) s

SUBMITTER: Wright ML 

PROVIDER: S-EPMC5811393 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature