Genetic correlation between smoking behaviors and schizophrenia.

ABSTRACT: Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h²_g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h²_g=0.08, age of onset of smoking h

SUBMITTER: Hartz SM 

PROVIDER: S-EPMC5811408 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature