AraGWAB: Network-based boosting of genome-wide association studies in Arabidopsis thaliana.

ABSTRACT: Genome-wide association studies (GWAS) have been applied for the genetic dissection of complex phenotypes in Arabidopsis thaliana. However, the significantly associated single-nucleotide polymorphisms (SNPs) could not explain all the phenotypic variations. A major reason for missing true phenotype-associated loci is the strict P-value threshold after adjustment for multiple hypothesis tests to reduce false positives. This statistical limitation can be partly overcome by increasing the sample size, but at a much higher cost. Alternatively, weak phenotype-association signals can be boosted by integrating other types of data. Here, we present a web application for network-based Arabidopsis genome-wide association boosting-araGWAB-which augments the likelihood of association with the given phe

SUBMITTER: Lee T 

PROVIDER: S-EPMC5811503 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature