Better and faster velocity pulsatility assessment in cerebral white matter perforating arteries with 7T quantitative flow MRI through improved slice profile, acquisition scheme, and postprocessing.

ABSTRACT:

Purpose

A previously published cardiac-gated 2D Qflow protocol at 7 T in cerebral perforating arteries was optimized to reduce velocity underestimation and improve temporal resolution.

Methods

First, the signal-to-noise ratio (SNR) gain of the velocity measurement (SNR_v ) was tested for two signal averages versus one. Second, the decrease in velocity underestimation with a tilted optimized nonsaturating excitation (TONE) pulse was tested. Third, the decrease in pulsatility index (PI) underestimation through improved temporal resolution was tested. Test-retest agreement was measured for the resulting acquisition in older volunteers (mean age 63 years), and the results were compared with the other volunteers (mean age 26 years).

Results

Using two signal avera

SUBMITTER: Geurts L 

PROVIDER: S-EPMC5811780 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature