Effects of repeated abobotulinumtoxinA injections in upper limb spasticity.

ABSTRACT:

Introduction

The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year.

Methods

Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500-U dose included 500-U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (X_V1, X_A ), angle of catch (X_V3 ), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score.

Results

The incidence of TEAEs decreased across cycles. Muscle tone reduction an

SUBMITTER: Gracies JM 

PROVIDER: S-EPMC5811783 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature