Choice of reference measurements affects quantification of long diffusion time behaviour using stimulated echoes.

ABSTRACT:

Purpose

To demonstrate how reference data affect the quantification of the apparent diffusion coefficient (ADC) in long diffusion time measurements with diffusion-weighted stimulated echo acquisition mode (DW-STEAM) measurements, and to present a modification to avoid contribution from crusher gradients in DW-STEAM.

Methods

For DW-STEAM, reference measurements at long diffusion times have significant b₀ value, because b = 0 cannot be achieved in practice as a result of the need for signal spoiling. Two strategies for acquiring reference data over a range of diffusion times were considered: constant diffusion weighting (fixed-b₀ ) and constant gradient area (fixed-q₀ ). Fixed-b₀ and fixed-q₀ were compared using signal cal

SUBMITTER: Kleinnijenhuis M 

PROVIDER: S-EPMC5811793 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature