Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.

ABSTRACT: BACKGROUND:Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine triphosphate (ATP) release from live and dying cells that enhances the inflammatory response of immune cells. Elevated extracellular levels ATP released upon injury activate purinergic pathways in inflammatory cells that promote migration, proliferation, phagocytosis, and apoptotic signals. Here, we tested whether trovafloxacin administration attenuates the neuroinflammatory response and improves outcomes after brain trauma. METHODS:The murine controlled cortical impact (CCI) model was used to determine whether in vivo delivery of trovafloxacin has anti-inflammatory and neuroprotective actions after brain trauma

SUBMITTER: Garg C 

PROVIDER: S-EPMC5812039 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature