FuSpot: a web-based tool for visual evaluation of fusion candidates.

ABSTRACT:

Background

Gene fusions often occur in cancer cells and in some cases are the main driver of oncogenesis. Correct identification of oncogenic gene fusions thus has implications for targeted cancer therapy. Recognition of this potential has led to the development of a myriad of sequencing-based fusion detection tools. However, given the same input, many of these detectors will find different fusion points or claim different sets of supporting data. Furthermore, the rate at which these tools falsely detect fusion events in data varies greatly. This discrepancy between tools underscores the fact that computation algorithms still cannot perfectly evaluate evidence; especially when provided with small amounts of supporting data as is typical in fusion detection. We assert that when evid

SUBMITTER: Killian JA 

PROVIDER: S-EPMC5812216 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature