Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset.

ABSTRACT: BACKGROUND:Abdominal aortic aneurysm (AAA) is a common cardiovascular system disease with high mortality. The aim of this study was to identify potential genes for diagnosis and therapy in AAA. METHODS:We searched and downloaded mRNA expression data from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) from AAA and normal individuals. Then, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, transcriptional factors (TFs) network and protein-protein interaction (PPI) network were used to explore the function of genes. Additionally, immunohistochemical (IHC) staining was used to validate the expression of identified genes. Finally, the diagnostic value of identified genes was accessed by receiver operating characteristic (RO

SUBMITTER: Wan L 

PROVIDER: S-EPMC5812227 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature