Metal ion assisted interface re-engineering of a ferritin nanocage for enhanced biofunctions and cancer therapy.

ABSTRACT: The bottom-up self-assembly of protein subunits into supramolecular nanoarchitectures is ubiquitously exploited to recapitulate and expand the features of natural proteins to advance nanoscience in medicine. Various chemical and biological re-engineering approaches are available to render diverse functions in the given proteins. They are, unfortunately, capable of compromising protein integrity and stability after extensive modifications. In this study, we introduce a new protein re-engineering method, metal ion assisted interface re-engineering (MAIR), to serve as a robust and universal strategy to extend the functions of self-assembly proteins by boosting structural features to advance their diverse biomedical applications. In particular, the MAIR strategy was applied to a widely used na

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5812362 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature