Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

ABSTRACT: The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6⁺ cells are unipotent progenitors, which expand clonally during puberty but diminish in adulthood. In pregnancy or following stimulation with ovarian hormones, adult Lgr6⁺ cells regained proliferative potency and their progeny formed alveoli over repeated pregnancies. Oncogenic mutations in Lgr6⁺ cells resulted in expansion of luminal cells, culminating in mamm

SUBMITTER: Blaas L 

PROVIDER: S-EPMC5812439 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature