Ontology highlight
ABSTRACT:
SUBMITTER: Blaas L
PROVIDER: S-EPMC5812439 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nature cell biology 20161031 12
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6<sup>+</sup> cells are unipotent progenitors, which expand clonally during puberty but diminish ...[more]