Genetic risk factors in Finnish patients with Parkinson's disease.

ABSTRACT:

Introduction

Variation contributing to the risk of Parkinson's disease (PD) has been identified in several genes and at several loci including GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT, but the frequencies of risk variants seem to vary according to ethnic background. Our aim was to analyze how variation in these genes contributes to PD in the Finnish population.

Methods

The subjects consisted of 527 Finnish patients with early-onset PD, 325 patients with late-onset PD and 403 population controls. We screened for known genetic risk variants in GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT. In addition, DNA from 225 patients with early-onset Parkinson's disease was subjected to whole exome sequencing (WES).

Results

We detected a significant difference in the length variat

SUBMITTER: Ylonen S 

PROVIDER: S-EPMC5812481 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature