Designing microorganisms for heterologous biosynthesis of cannabinoids.

ABSTRACT: During the last decade, the use of medical Cannabis has expanded globally and legislation is getting more liberal in many countries, facilitating the research on cannabinoids. The unique interaction of cannabinoids with the human endocannabinoid system makes these compounds an interesting target to be studied as therapeutic agents for the treatment of several medical conditions. However, currently there are important limitations in the study, production and use of cannabinoids as pharmaceutical drugs. Besides the main constituent tetrahydrocannabinolic acid, the structurally related compound cannabidiol is of high interest as drug candidate. From the more than 100 known cannabinoids reported, most can only be extracted in very low amounts and their pharmacological profile has not been dete

SUBMITTER: Carvalho A 

PROVIDER: S-EPMC5812543 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature