Survival from alcoholic hepatitis has not improved over time.

ABSTRACT:

Purpose/background

We aimed to describe changes in survival in alcoholic hepatitis (AH) over time by examining published data.

Methods

A systematic literature search of Ovid Embase and PubMed was undertaken using the MESH terms 'hepatitis, alcoholic' to identify randomised controlled trials (RCT) and observational studies (OS) in alcoholic hepatitis. Data were extracted from included studies regarding 28-day, 90-day, 180-day mortality, as well as biochemical and clinical data.

Results

After review of the literature search results, 77 studies published between 1971 and 2016 were analysed, which included data from a total of 8,184 patients. Overall mortality from AH was 26% at 28 days, 29% at 90 days and 44% at 180 days after admission. No changes in mortality over time

SUBMITTER: Hughes E 

PROVIDER: S-EPMC5812634 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature