The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.

ABSTRACT:

Background

Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive.

Objective

A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met).

Data sources

PubMed, Embase, PsychInfo.

Study eligibility criteria

All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome.

Study appraisal and synthesis methods

A meta-analysis was performed using the Meta-analysis of Observational Studies in Epidemiology guidelines and forest plots were

SUBMITTER: Vaessen TSJ 

PROVIDER: S-EPMC5812637 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature